Aerobic exercise improves the inflammatory profile correlated with cardiac remodeling and function in chronic heart failure rats
Clinics
; Clinics;68(6): 876-882, jun. 2013. tab, graf
Article
in En
| LILACS
| ID: lil-676949
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
The aim of the present study was to evaluate the effect of 8 weeks of aerobic exercise training on cardiac functioning and remodeling and on the plasma levels of inflammatory cytokines in chronic heart failure rats.METHODS:
Wistar rats were subjected to myocardial infarction or sham surgery and assigned to 4 groups chronic heart failure trained (n = 7), chronic heart failure sedentary (n = 6), sham trained (n = 8) and sham sedentary (n = 8). Four weeks after the surgical procedures, the rats were subjected to aerobic training in the form of treadmill running (50 min/day, 5 times per week, 16 m/min). At the end of 8 weeks, the rats were placed under anesthesia, the hemodynamic variables were recorded and blood samples were collected. Cardiac hypertrophy was evaluated using the left ventricular weight/body weight ratio, and the collagen volume fraction was assessed using histology.RESULTS:
The chronic heart failure trained group showed a reduction in left ventricular end-diastolic pressure, a lower left ventricular weight/body weight ratio and a lower collagen volume fraction compared with the chronic heart failure sedentary group. In addition, exercise training reduced the plasma levels of TNF-α and IL-6 and increased the plasma level of IL-10.CONCLUSION:
An 8-week aerobic exercise training program improved the inflammatory profile and cardiac function and attenuated cardiac remodeling in chronic heart failure rats. .Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Physical Conditioning, Animal
/
Inflammation Mediators
/
Ventricular Remodeling
/
Exercise Therapy
/
Heart Failure
Type of study:
Evaluation_studies
Limits:
Animals
Language:
En
Journal:
Clinics
Journal subject:
MEDICINA
Year:
2013
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil