Atypical chronic myeloid leukemia with t(9; 22)(p24,11. 2), a BCR-JAK2 fusion gene
Rev. bras. hematol. hemoter
; 35(3): 218-219, jun. 2013. tab, graf
Article
in English
| LILACS
| ID: lil-681980
Responsible library:
BR408.1
Localization: BR408.1
ABSTRACT
We report here on a rare case of BCR-ABL1-negative atypical chronic myeloid leukemia with a t(9;22)(p24;q11.2)translocation and a BCR-JAK2 fusion gene, with resistance to the tyrosine kinase inhibitors imatinib and dasatinib.At two years of follow-up, the patient showed no hematologic response and was submitted to an allogeneic bonemarrow transplantation. Fifty-three days after the procedure, he died due to acute graft-versus-host disease. This BCR-JAK2 fusion gene has so far been found in only five patients in the whole world, with three clinical presentations myeloproliferative neoplasm, acute lymphoblastic leukemia and acute myeloid leukemia.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Leukemia, Myeloid
/
Proto-Oncogene Proteins c-bcr
/
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
/
Myelodysplastic-Myeloproliferative Diseases
Limits:
Humans
/
Male
Language:
English
Journal:
Rev. bras. hematol. hemoter
Journal subject:
Hematology
Year:
2013
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto HEMOMED/BR