Effects of atropine and propranolol on lung inflammation in experimental envenomation: comparison of two buthidae venoms
J. venom. anim. toxins incl. trop. dis
; 19: 8-8, maio 2013. ilus
Article
in English
| LILACS
| ID: lil-686617
Responsible library:
BR33.1
ABSTRACT
Background:
Previous works had shown that scorpion venom induced neurotransmitter elevation and an inflammatory response associated with various anatomo-pathological modifications. The most dangerous scorpions species in Algeria responsible for these effects are Androctonus australis hector (Aah) and Androctonus amoreuxi (Aam).Results:
Comparison of the physiopathological effects induced by the two venoms showed differences in the kinetic of cytokine release and in lung injury. The lung edema was only observed in response to Aah venom and it was correlated with cell infiltration. In order to better understand the involved mechanism in inflammatory response, we used two antagonists, atropine (non-selective muscarinic antagonist) and propranolol (ß adrenergic antagonist), which lead to a decrease of cell infiltration but has no effect on edema forming.Conclusion:
These results suggest another pathway in the development of lung injury following envenomation with Aam or Aah venom.(AU)
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Target 3.3 End transmission of communicable diseases
Health problem:
Pneumonia
Database:
LILACS
Main subject:
Pneumonia
/
Atropine
/
Scorpion Venoms
/
1-Propanol
Limits:
Animals
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Journal subject:
Toxicology
Year:
2013
Document type:
Article
Affiliation country:
Algeria
Institution/Affiliation country:
University of Sciences and Technology/DZ