Lack of association of S100 and neuron-specific enolase with mortality in critically ill patients
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 35(3): 267-270, Jul-Sep. 2013. tab
Article
in English
| LILACS
| ID: lil-687944
Responsible library:
BR1.1
ABSTRACT
Objective:
To evaluate the relationship between brain damage biomarkers and mortality in the intensive care unit (ICU).Methods:
The sample comprised 70 patients admitted to an ICU. Blood samples were collected from all patients on ICU admission, and levels of S100β and neuron-specific enolase (NSE) were determined by ELISA.Results:
Acute Physiologic and Chronic Health Evaluation (APACHE II) score was associated with mortality, but NSE and S100β were not associated with this outcome. In contrast, S100β levels were significantly higher in delirious and non-delirious patients who required mechanical ventilation during ICU stay.Conclusion:
Levels of brain biomarkers at the time of ICU admission did not predict mortality in critically ill patients. .
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Mental Health and Behavioral Disorders
Database:
LILACS
Main subject:
Phosphopyruvate Hydratase
/
Brain Injuries
/
Critical Illness
/
Delirium
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2013
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
National Science and Technology Institute for Translational Medicine/BR
