Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma
J. appl. oral sci
; 21(5): 416-421, Sep-Oct/2013. tab, graf
Article
in English
| LILACS, BBO - Dentistry
| ID: lil-690094
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
This study aimed to investigate the expression of the MSH2 DNA repair protein in head and neck squamous cell carcinoma (HNSCC) in order to analyze its association with clinicopathologic factors and overall survival of patients. MATERIAL ANDMETHODS:
Clinical data and primary lesions of HNSSC were collected from 55 patients who underwent surgical resection with postoperative radiotherapy in Montes Claros, state of Minas Gerais, Brazil, between 2000 and 2008. Immunohistochemical reactions were performed to analyze MSH2 protein expression.RESULTS:
Bivariate analysis showed no significant correlation or association between MSH2 expression and clinicopathologic parameters by Mann-Whitney and Kruskal-Wallis tests. Patients with locoregional metastatic disease (OR=4.949, p<0.001) and lower MSH2 immunohistochemical expressions (OR=2.943, p=0.032) presented poorer survival for HNSCC by Cox regression models.CONCLUSIONS:
Our data demonstrated that lower MSH2 expression might contribute to a higher clinic aggressiveness of HNSCC by promoting an unfavorable outcome. .
Full text:
Available
Collection:
International databases
Database:
BBO - Dentistry
/
LILACS
Main subject:
Carcinoma, Squamous Cell
/
DNA Repair
/
Head and Neck Neoplasms
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
J. appl. oral sci
Journal subject:
Dentistry
Year:
2013
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual de Montes Claros/BR