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Vasorelaxant effects in aortic rings of eight diterpenoids isolated from three Venezuelan plants
Mondolis, Eily; Moran-Pinzon, Juan Antonio; Rojas-Marquez, Focion Alberto; Lopez-Perez, Jose Luis; Abad, Andres; Amaro-Luis, Juan Manuel; Leon, Estela Guerrero De.
Affiliation
  • Mondolis, Eily; Universidad de Panama. Facultad de Medicina. Departamento de Farmacologia. Panama City. PA
  • Moran-Pinzon, Juan Antonio; Universidad de Panama. Facultad de Medicina. Departamento de Farmacologia. Panama City. PA
  • Rojas-Marquez, Focion Alberto; Universidad de Panama. Facultad de Medicina. Departamento de Farmacologia. Panama City. PA
  • Lopez-Perez, Jose Luis; Universidad de Panama. Facultad de Medicina. Departamento de Farmacologia. Panama City. PA
  • Abad, Andres; Universidad de Panama. Facultad de Medicina. Departamento de Farmacologia. Panama City. PA
  • Amaro-Luis, Juan Manuel; Universidad de Panama. Facultad de Medicina. Departamento de Farmacologia. Panama City. PA
  • Leon, Estela Guerrero De; Universidad de Panama. Facultad de Medicina. Departamento de Farmacologia. Panama City. PA
Rev. bras. farmacogn ; 23(5): 769-775, Sep-Oct/2013. tab, graf
Article in English | LILACS | ID: lil-697303
Responsible library: BR1.1
ABSTRACT
Vasorelaxant activity Vasorelaxant effects of eight diterpenoids isolated from three Venezuelan plants [(+)-manool [(+)-labda-8(17),14-dien-13-ol], (+)-manoyl oxide, (+)-2-oxomanoyl oxide, sandaracopimara-8(14), 15-dien-3β, 19-diol, jhanidiol acetate (18-acetoxy-1βhydroxymanoyl oxide), jhanidiol (1β,18-dihydroxymanoyl oxide), ent-kaur-16-en-19ol and grandiflorenic acid (ent-kaur-9(11),16-dien-19-oic acid)] aortic rings were assessed in intact endothelium and endothelium-denuded isolated rat. Thw cumulative addition (10-6 to 10-4 M) of each product were carried out after contraction with phenylephrine (10-6 M). Jhanidiol acetate and ent-kaur-9,16-en-19-oic acid at 10-4 M dose concentration, exhibit the maximal vasorelaxant effect in endothelium-intact rings (51.61 ± 7.62% and 79.27 ± 7.41%, respectively). In endothelium-denuded aortic rings, the maximum vascular response exerted by both compounds was not abolished (64.14 ± 5.64% and 84.84 ± 3.62%, respectively). In denuded aortic rings, the half-maximal inhibitory concentration (IC50) Jhanidiol was obtained by the ethyl less than those obtained in rings endothelium (1.09 × 10-4 vs 7.29 × 10-5 M, respectively), although this difference was not significant. These results suggested that the mechanism behind the vasorelaxant effect of the two diterpene is mediated by endothelium-independent pathways.


Full text: Available Collection: International databases Database: LILACS Country/Region as subject: South America / Venezuela Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2013 Document type: Article / Project document Affiliation country: Panama Institution/Affiliation country: Universidad de Panama/PA

Full text: Available Collection: International databases Database: LILACS Country/Region as subject: South America / Venezuela Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2013 Document type: Article / Project document Affiliation country: Panama Institution/Affiliation country: Universidad de Panama/PA
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