Comparative study of the kidneys from dystrophic mice
Braz. j. morphol. sci
; 30(3): 186-190, 2013. ilus, tab
Article
in En
| LILACS
| ID: lil-699347
Responsible library:
BR734.1
ABSTRACT
The Duchenne Muscular Dystrophy (DMD) is a recessive genetic disease linked to chromosome X. Thisdisease is characterized by an absence or dysfunction in the expression of dystrophin. Experimental modelsmdxare widely used for the development of research addressing the DMD. The objective of this research is tocontribute to a detailed study of possible renal morphological changes resulting from DMD. We used five pairsof kidneys frommdxmice and five from normal mice, which were subjected to measurement, light microscopy,and scanning electron microscopy. The morphological findings of kidneys frommdxmice are within thepatterns described in animal studies with severe dehydration, which exhibit signs of diffuse hemorrhage inthe cortical and medullary area, while the glomeruli in the cortical region showed a decrease in urinary space,located between the Bowmans capsule and the inner cell mass of the glomeruli. However, future experimentswith animals in different ages can assist in the proving of the morphological changes found here.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Muscular Dystrophy, Duchenne
/
Dehydration
/
Kidney
/
Kidney Glomerulus
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Braz. j. morphol. sci
Journal subject:
ANATOMIA
Year:
2013
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil