Infecciones respiratorias en niños con síndrome de Down / Respiratory infections in children with Down syndrome
Neumol. pediátr
; 8(1): 22-26, 2013. tab, ilus
Article
in Spanish
| LILACS
| ID: lil-701686
Responsible library:
CL1.1
ABSTRACT
Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. Non-immunological factors, including abnormal anatomical structures, congenital heart disease and gastro esophageal reflux, may play a role in the increased frequency of respiratory tract infections. Addressing immunological and non-immunological factors involved in the pathogenesis of infectious diseases may reduce the susceptibility to infections in DS children.
RESUMEN
Síndrome de Down (SD) es la anormalidad cromosómica más común entre los recién nacidos vivos. Las infecciones respiratorias son la causa más importante de mortalidad en individuos con SD en todas las edades. En las últimas décadas se han realizado varios estudios para aclarar las anormalidades del sistema inmune en SD. Factores no-inmunológicos, incluyendo estructuras anatómicas anormales, enfermedad cardíaca congénita y reflujo gastroesofágico, pueden desempeñar un papel en el aumento de la frecuencia de infecciones del tracto respiratorio. Abordar los factores inmunológicos y no inmunológicos implicados en la patogenia de las enfermedades infecciosas puede reducir la susceptibilidad a las infecciones en los niños SD.
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Collection:
International databases
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
/
SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Goal 9: Noncommunicable diseases and mental health
/
Target 3.4: Reduce premature mortality due to noncommunicable diseases
/
Target 3.2: Reduce avoidable death in newborns and children under 5
/
Congenital and Chromosomal Anomalies
/
Other Respiratory Diseases
/
Neonatal Healthcare
Database:
LILACS
Main subject:
Respiratory Tract Infections
/
Down Syndrome
Limits:
Child
/
Humans
Language:
Spanish
Journal:
Neumol. pediátr
Journal subject:
Pediatrics
/
Pulmonary Disease (Specialty)
Year:
2013
Document type:
Article
Affiliation country:
Venezuela
Institution/Affiliation country:
Clínica Leopoldo Aguerrevere/VE
/
Hospital San Juan de Dios Caracas/VE
/
Hospital San Juan de Dios/VE
/
Instituto Médico la Floresta/VE