Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
Rev. Soc. Bras. Med. Trop
; 47(1): 90-92, Jan-Feb/2014. tab
Article
in English
| LILACS
| ID: lil-703154
Responsible library:
BR1.1
ABSTRACT
Introduction:
The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression.Methods:
Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation.Results:
Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis.Conclusions:
HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction. .
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Hepacivirus
/
Hepatitis C, Chronic
/
Liver Cirrhosis
Type of study:
Diagnostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2014
Document type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Para/BR