Cáncer de mama en mujeres adultas mayores, características clínicas e histopatológicas y resultados del tratamiento con intención curativa / Characteristics and results of breast cancer in elderly females treated with curative inten
Rev. méd. Chile
; 141(12): 1534-1540, dic. 2013. graf, tab
Article
in Es
| LILACS
| ID: lil-705572
Responsible library:
CL1.1
ABSTRACT
Background:
Aging is the main risk factor to acquire breast cancer (BC). Nevertheless BC in elderly patients is sub-represented in clinical trials.Aim:
To describe the clinical characteristics and long term treatment results of localized BC in older women. Material andMethods:
Review of medical records of 65 women aged 70 to 88 years, with localized BC, treated with surgery, postoperative radiotherapy or systemic therapy at a Clinical Hospital in Chile.Results:
The presence of symptoms or abnormal findings on physical examination were the main reasons for consulting in 65% of cases. Compared with tumors detected on physical examination, those detected using screening mammogram were smaller and were in stage 1 with a higher frequency (18 and 59% respectively, p < 0.01). The pathological type was luminal in 80% of cases. Overall survival was better for luminal pathological type. All patients completed radiotherapy without interruptions developing minor acute toxicity. The most common co-morbidity was high blood pressure occurring in 46% of patients. Thirteen percent of patients had three or more co-morbidities. After a median follow up of 7 years, 23 (35%) patients had died and the cause of death was BC in 43% of cases. Two patients died of lung cancer. No patient had a local breast relapse.Conclusions:
Screening mammogram in older women detected smaller tumors and it was associated with a better survival. BC is the ultimate cause of death in approximately half of cases.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Breast Neoplasms
/
Carcinoma, Ductal, Breast
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
Country/Region as subject:
America do sul
/
Chile
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2013
Document type:
Article
Affiliation country:
Chile
Country of publication:
Chile