Influence of water pH in oral changes caused by cadmium poisoning: an experimental study in rats / Influência do pH da água nas alterações bucais causadas pela intoxicação por cádmio: um estudo experimental em ratos
Rev. odontol. UNESP (Online)
; 43(3): 180-184, May-Jun/2014. tab, ilus
Article
in English
| LILACS, BBO - Dentistry
| ID: lil-710393
Responsible library:
BR39.2
ABSTRACT
Objective:
This study aims to evaluate the effect of the pH of drinking water in the oral changes caused by cadmium poisoning. Material andmethod:
Ninety male Wister rats were divided into the following six groups A - 15 rats were given cadmium chloride solution (400 mg/L) in drinking water with a neutral pH (pH 7.0); B - 15 rats received cadmium chloride solution (400 mg/L) in drinking water with an acidic pH (pH 5.0); C - 15 rats were treated with a cadmium chloride solution (400 mg/L) in drinking water with a basic pH (pH 8.0); D - 15 rats received drinking water with an acidic pH (pH 5.0); E - 15 rats were given drinking water with a basic pH (pH 8.0); F - 15 rats received water with a neutral pH (pH 7.0). All animals were sacrificed six months after the beginning of the experiment. A biopsy of the buccal mucosa, tongue and salivary gland of each animal was taken for microscopic analysis.Result:
No changes were observed in the buccal mucosa, tongue mucosa or salivary glands in any of the groups.Conclusion:
Drinking water that contains a high concentration of cadmium with differing pH levels demonstrated no damage to the oral mucosa and salivary glands of male Wistar rats. .RESUMO
Objetivo:
Avaliar o efeito do pH da água de beber nas alterações bucais provocadas pela intoxicação por cádmio. Material emétodo:
Foram utilizados 90 ratos Wistar, adultos, machos, divididos em 6 grupos A - 15 ratos que receberam solução de cloreto de cádmio (400 mg/L) na água de beber com pH neutro (pH 7,0); B -15 ratos que receberam solução de cloreto de cádmio (400 mg/L) na água com pH ácido (pH 5,0); C - 15 ratos, os quais receberam solução de cloreto de cádmio (400mg/L) na água com pH básico (pH 8,0). D - 15 ratos que receberam água com pH ácido (pH 5,0); E - 15 ratos que receberam água com pH básico (pH 8,0); F -15 ratos que receberam água com pH neutro (pH 7,0). Todos os animais foram eutanasiados 6 meses após o início do experimento. Foram retirados fragmentos da mucosa jugal, língua e glândula salivar de cada animal para análise microscópica.Resultado:
Não foram observadas alterações na mucosa jugal, mucosa da língua ou nas glândulas salivares em nenhum dos grupos avaliados.Conclusão:
Mesmo em alta concentração o cádmio adicionado à água de beber não mostrou causar dano a mucosa bucal ou às glândulas salivares, independente do pH da água. .
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Target 3.9 Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
/
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Unintentional Poisoning
/
Target 3.9: Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
/
Zoonoses
Database:
BBO - Dentistry
/
LILACS
Main subject:
Poisoning
/
Cadmium
/
Mouth Neoplasms
/
Statistics, Nonparametric
/
Environmental Exposure
Limits:
Animals
Language:
English
Journal:
Rev. odontol. UNESP (Online)
Journal subject:
Dentistry
Year:
2014
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade do Oeste Paulista/BR