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Leprosy: a review of laboratory and therapeutic aspects - Part 2
Lastória, Joel Carlos; Abreu, Marilda Aparecida Milanez Morgado de.
Affiliation
  • Lastória, Joel Carlos; Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Medicina de Botucatu. Botucatu. BR
  • Abreu, Marilda Aparecida Milanez Morgado de; Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Medicina de Botucatu. Botucatu. BR
An. bras. dermatol ; 89(3): 389-401, May-Jun/2014. graf
Article in English | LILACS | ID: lil-711618
Responsible library: BR1.1
ABSTRACT
Leprosy is a chronic infectious condition caused by Mycobacterium leprae(M. leprae). It is endemic in many regions of the world and a public health problem in Brazil. Additionally, it presents a wide spectrum of clinical manifestations, which are dependent on the interaction between M. leprae and host, and are related to the degree of immunity to the bacillus. The diagnosis of this disease is a clinical one. However, in some situations laboratory exams are necessary to confirm the diagnosis of leprosy or classify its clinical form. This article aims to update dermatologists on leprosy, through a review of complementary laboratory techniques that can be employed for the diagnosis of leprosy, including Mitsuda intradermal reaction, skin smear microscopy, histopathology, serology, immunohistochemistry, polymerase chain reaction, imaging tests, electromyography, and blood tests. It also aims to explain standard multidrug therapy regimens, the treatment of reactions and resistant cases, immunotherapy with bacillus Calmette-Guérin (BCG) vaccine and chemoprophylaxis.
Subject(s)


Full text: Available Collection: International databases Health context: SDG3 - Health and Well-Being / Neglected Diseases Health problem: Target 3.3: End transmission of communicable diseases / Leprosy / Neglected Diseases / Tuberculosis / Zoonoses Database: LILACS Main subject: Leprosy, Multibacillary / Leprosy, Paucibacillary / Mycobacterium leprae Type of study: Diagnostic study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2014 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista Júlio de Mesquita Filho/BR

Full text: Available Collection: International databases Health context: SDG3 - Health and Well-Being / Neglected Diseases Health problem: Target 3.3: End transmission of communicable diseases / Leprosy / Neglected Diseases / Tuberculosis / Zoonoses Database: LILACS Main subject: Leprosy, Multibacillary / Leprosy, Paucibacillary / Mycobacterium leprae Type of study: Diagnostic study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2014 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista Júlio de Mesquita Filho/BR
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