Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood
Psychol. neurosci. (Impr.)
; 7(2): 125-130, Jan.-June 2014. ilus
Article
in English
| LILACS
| ID: lil-718327
Responsible library:
BR85.1
ABSTRACT
The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood...
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Cell Hypoxia
/
Cell Survival
/
Motor Activity
Limits:
Animals
Language:
English
Journal:
Psychol. neurosci. (Impr.)
Journal subject:
Neurology
/
Psychology
Year:
2014
Document type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de São Paulo/BR