Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant
Acta cir. bras
; 29(supl.1): 12-18, 2014. tab, graf
Article
in English
| LILACS
| ID: lil-720407
Responsible library:
BR1.1
ABSTRACT
PURPOSE:
To evaluate the tissue response of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant.METHODS:
A total of 20 male guinea pigs were divided into 2 groups. After paracentesis in both ears, a biodegradable polymer of poly lactic-co-glycolic acid was implanted in only one middle ear. Histological analysis using neutrophil exudate and vascular neoformation (acute inflammation) and fibroblast proliferation and mononuclear inflammatory cells (chronic inflammation) as parameters was performed after 10 and 30 days of survival (groups 1 and 2, respectively).RESULTS:
Four ears in group 1 and 7 in group 2 had an increase of neutrophil exudate. Vascular neoformation occurred in ears with or without the implant, in both groups. Fibroblast proliferation and mononuclear inflammatory cells (lymphocytes and macrophages) increased in ears with implant in group 2.CONCLUSION:
The tissue response by histological analysis of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant, showed no statistically significant difference between ears with or without the implant. .
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Polymers
/
Thioctic Acid
/
Absorbable Implants
/
Ear, Middle
/
Lactates
Type of study:
Evaluation study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2014
Document type:
Article
Affiliation country:
Brazil