Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylori
J. venom. anim. toxins incl. trop. dis
; 2004/02/2014.
Article
in English
| LILACS
| ID: lil-724684
Responsible library:
BR68.1
ABSTRACT
Epidemiological investigations have indicated that Helicobacter pylori induces inflammation in the gastric mucosa regulated by several interleukins. The genes IL1B and IL8 are suggested as key factors in determining the risk of gastritis. The aim of this paper was to evaluate the association of gene polymorphism of interleukin-1 and interleukin-8 with chronic gastrits in H. pylori infected patients. A total of 60 patients underwent endoscopic procedure. Biopsy samples were collected for urease test, histopathological and molecular exams. The DNA of theses samples was extracted for detection of H. pylori and analysis of the genes mentioned above. Patients with gastritis had a higher frequency of H. pylori-positive samples.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Polymorphism, Genetic
/
Interleukin-1
/
Helicobacter
/
Gastritis
Limits:
Animals
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Journal subject:
Toxicology
Year:
2014
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade de Medicina de Marília/BR
/
Universidade do Sagrado Coração/BR