T regulatory cells (TREG)(TCD4+CD25+FOXP3+) distribution in the different clinical forms of leprosy and reactional states
An. bras. dermatol
; 90(1): 41-47, Jan-Feb/2015. tab, graf
Article
in English
| LILACS
| ID: lil-735739
Responsible library:
BR1.1
ABSTRACT
BACKGROUND:
Leprosy is characterized histologically by a spectrum of different granulomatous skin lesions, reflecting patients' immune responses to Mycobacterium leprae. Although CD4+CD25+ FoxP3+ T regulatory cells are pivotal in the immuneregulation, presence, frequency, and distribution of Tregs in leprosy, its reactional states have been investigated in few studies.OBJECTIVES:
This study aimed to verify the frequency and distribution of regulatory T cells in different clinical forms and reactional states of leprosy.METHODS:
We performed an immunohistochemical study on 96 leprosy cases [Indeterminate (I) 9 patients; tuberculoid tuberculoid 13 patients; borderline tuberculoid 26 patients; borderline borderline 3 patients; borderline lepromatous 8 patients; lepromatous lepromatous 27 patients; reversal reaction 8 patients; and erythema nodosum leprosum 2 patients].RESULTS:
FoxP3-positive cells were present in 100% of the cases with an average density of 2.82% of the infiltrate. Their distribution was not related to granulomatous structures or special locations. There was a statistically significant increment of FoxP3 expression in patients with leprosy reversal reactions when compared with patients presenting with type I leprosy (P= 0.0228); borderline tuberculoid leprosy (P = 0.0351) and lepromatous leprosy (P = 0.0344).CONCLUSIONS:
These findings suggest that Tregs play a relevant role in the etiopathogenesis of leprosy, mainly in type I leprosy reaction. .
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Leprosy
/
Neglected Diseases
Database:
LILACS
Main subject:
T-Lymphocytes, Regulatory
/
Granuloma
/
Leprosy
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2015
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Centro Universitário Christus/BR