Comparison of pre- and post-levothyroxine high-sensitivity c-reactive protein and fetuin-a levels in subclinical hypothyroidism
Clinics
; Clinics;70(2): 97-101, 2/2015. tab
Article
in En
| LILACS
| ID: lil-741427
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
The objective of this trial was to determine the levels of inflammatory markers, high-sensitivity C-reactive protein and fetuin-A pre- and post-levothyroxine treatment in cases of subclinical hypothyroidism. MATERIALS ANDMETHODS:
A total of 32 patients with a diagnosis of subclinical hypothyroidism and a control group of 30 healthy individuals were tested for high-sensitivity C-reactive protein and fetuin-A, followed by the administration of 50 µg of levothyroxine in the patient group for 3 months. During the post-treatment stage, high-sensitivity C-reactive protein and fetuin-A levels in the patient group were re-assessed and compared with pre-treatment values.RESULTS:
Pre-treatment levels of both high-sensitivity C-reactive protein and fetuin-A were observed to be higher in the patient group than in the control group. The decrease in high-sensitivity C-reactive protein levels during the post-treatment stage was not statistically significant. However, the decrease observed in post-treatment fetuin-A levels was found to be statistically significant.CONCLUSION:
The decrease in fetuin-A levels in subclinical hypothyroidism cases indicates that levothyroxine treatment exerts anti-inflammatory and anti-apoptotic effects. Although the decrease in high-sensitivity C-reactive protein levels was statistically non-significant, it is predicted to reach significance with sustained treatment. .Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Sputum
/
Tuberculosis, Pulmonary
/
Microscopy
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Adolescent
/
Adult
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Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Clinics
Journal subject:
MEDICINA
Year:
2015
Document type:
Article
Affiliation country:
Turkey
Country of publication:
Brazil