Antimicrobial and cytotoxic effects of phosphoric acid solution compared to other root canal irrigants
J. appl. oral sci
; 23(2): 158-163, Mar-Apr/2015. tab, graf
Article
in English
| LILACS, BBO - Dentistry
| ID: lil-746546
Responsible library:
BR1.1
ABSTRACT
Phosphoric acid has been suggested as an irrigant due to its effectiveness in removing the smear layer. Objectives:
The purpose of this study was to compare the antimicrobial and cytotoxic effects of a 37% phosphoric acid solution to other irrigants commonly used in endodontics. Material andMethods:
The substances 37% phosphoric acid, 17% EDTA, 10% citric acid, 2% chlorhexidine (solution and gel), and 5.25% NaOCl were evaluated. The antimicrobial activity was tested against Candida albicans, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Actinomyces meyeri, Parvimonas micra, Porphyromonas gingivalis, and Prevotella nigrescens according to the agar diffusion method. The cytotoxicity of the irrigants was determined by using the MTT assay.Results:
Phosphoric acid presented higher antimicrobial activity compared to the other tested irrigants. With regard to the cell viability, this solution showed results similar to those with 5.25% NaOCl and 2% chlorhexidine (gel and solution), whereas 17% EDTA and 10% citric acid showed higher cell viability compared to other irrigants.Conclusion:
Phosphoric acid demonstrated higher antimicrobial activity and cytotoxicity similar to that of 5.25% NaOCl and 2% chlorhexidine (gel and solution). .
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Target 3.9 Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
Health problem:
Occupational Exposures
Database:
BBO - Dentistry
/
LILACS
Main subject:
Radiation Injuries
/
Burns
/
Occupational Exposure
/
Hyperbaric Oxygenation
/
Iridium
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
J. appl. oral sci
Journal subject:
Dentistry
Year:
2015
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
State University of Campinas/BR