Vitamin D deficiency is independently associated with mortality among critically ill patients
Clinics
; 70(5): 326-332, 05/2015. tab, graf
Article
in English
| LILACS
| ID: lil-748274
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
Studies suggest an association between vitamin D deficiency and morbidity/mortality in critically ill patients. Several issues remain unexplained, including which vitamin D levels are related to morbidity and mortality and the relevance of vitamin D kinetics to clinical outcomes. We conducted this study to address the association of baseline vitamin D levels and vitamin D kinetics with morbidity and mortality in critically ill patients.METHOD:
In 135 intensive care unit (ICU) patients, vitamin D was prospectively measured on admission and weekly until discharge from the ICU. The following outcomes of interest were analyzed 28-day mortality, mechanical ventilation, length of stay, infection rate, and culture positivity.RESULTS:
Mortality rates were higher among patients with vitamin D levels <12 ng/mL (versus vitamin D levels >12 ng/mL) (32.2% vs. 13.2%), with an adjusted relative risk of 2.2 (95% CI 1.07-4.54; p< 0.05). There were no differences in the length of stay, ventilation requirements, infection rate, or culture positivity.CONCLUSIONS:
This study suggests that low vitamin D levels on ICU admission are an independent risk factor for mortality in critically ill patients. Low vitamin D levels at ICU admission may have a causal relationship with mortality and may serve as an indicator for vitamin D replacement among critically ill patients. .
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Target 3.9 Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
/
SDG3 - Health and Well-Being
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Occupational Exposures
/
Target 3.9: Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
/
Endocrine System Diseases
/
Obesity
/
Other Respiratory Diseases
Database:
LILACS
Main subject:
Occupational Exposure
/
Firefighters
/
Metabolic Syndrome
/
Air Pollutants, Occupational
/
Dust
/
Lung Diseases, Obstructive
Type of study:
Diagnostic study
/
Etiology study
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Observational study
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Prognostic study
/
Risk factors
Limits:
Adult
/
Humans
Country/Region as subject:
North America
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2015
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Rio Grande do Sul/BR