Mean platelet volume is associated with disease severity in patients with obstructive sleep apnea syndrome
Clinics
; 70(7): 481-485, 2015. tab
Article
in English
| LILACS
| ID: lil-752398
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
Obstructive sleep apnea syndrome is associated with cardiovascular diseases and thromboembolic events. The mean platelet volume (MPV) is a predictor of cardiovascular thromboembolic events. The aim of the present study is to investigate the association between the MPV and disease severity in patients with obstructive sleep apnea syndrome.METHODS:
We prospectively included 194 obstructive sleep apnea syndrome patients without cardiovascular disease (mean age 56.5±12.5 years) who were undergoing sleep tests. An overnight full laboratory polisomnography examination was conducted on each patient. The patients were divided into 3 groups according to the apnea-hypopnea index (AHI) (1) AHIlow group 5≤AHI<15, (2) AHImid group 15<AHI≤30, and (3) AHIhigh group AHI>30.RESULTS:
The highest MPV values were found in the AHIhigh group compared with other groups (p<0.05 for all). Multiple linear regression analysis indicated that the MPV was associated with the AHI (β=0.500, p<0.001) and the high sensitivity C-reactive protein (hs-CRP) level (β=0.194, p=0.010).CONCLUSION:
The MPV is independently associated with both disease severity and inflammation in patients with obstructive sleep apnea syndrome. .
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Platelet Count
/
C-Reactive Protein
/
Sleep Apnea, Obstructive
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2015
Document type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Adana Numune Training and Research Hospital/TR