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O transtorno glutamatérgico na esquizofrenia / Glutamatergic disorder in schizophrenia
Naief, Cleber; Tavares, Almir.
Affiliation
  • Naief, Cleber; Universidade Federal de Minas Gerais. Faculdade de Medicina. BR
  • Tavares, Almir; Universidade Federal de Minas Gerais. Faculdade de Medicina. BR
Rev. méd. Minas Gerais ; 7(1): 23-27, jan.-mar. 1997. tab
Article in Portuguese | LILACS | ID: lil-755246
Responsible library: BR21.1
RESUMO
A excitoxicidade relacionada ao neurotransmissor aminoácido glu- ta mato e ao seu receptor NMDA (n-metil-d-aspartato) consiste em um mecanismo de elevado potencial para explicar a fisiopatologia da esquizofrenia. Os neurolépticos atípicos clozapina e olanzapia têm potencial para proteger contra a neurotoxicidade gerada pelos antagonistas de NMDA.
ABSTRACT
Excitotocicity due to glutamate and its NMDA (N-methyl-D- aspartate) receptor are a possible mechanism for the physiopatholoy of schizophrenia. The atipical neuroleptic drugs clozapine and olanzapina present the potencial to protect against neu- rorocity caused by NMDA antagonists.
Subject(s)

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Collection: International databases Database: LILACS Main subject: Schizophrenia / Receptors, N-Methyl-D-Aspartate / Glutamic Acid Limits: Humans Language: Portuguese Journal: Rev. méd. Minas Gerais Journal subject: Medicine Year: 1997 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR
Search on Google
Add to My VHL
Print
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Collection: International databases Database: LILACS Main subject: Schizophrenia / Receptors, N-Methyl-D-Aspartate / Glutamic Acid Limits: Humans Language: Portuguese Journal: Rev. méd. Minas Gerais Journal subject: Medicine Year: 1997 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR