Penile reconstruction using mesenchymal stem cells
Acta cir. bras
; 30(8): 529-536, Aug. 2015. ilus
Article
in English
| LILACS
| ID: lil-757991
Responsible library:
BR1.1
ABSTRACT
PURPOSE:
To compare the reconstruction of corpus cavernosum segments when seeded with mesenchymal stem cells and when stem cells are infused intravenously.METHODS:
Sixteen New Zealand rabbits were submitted to reconstruction of the corpus cavernosum and distributed in Group A - decellularized matrices, Group B - decellularized matrices seeded with mesenchymal stem cells Group C - decellularized matrices submitted to intravenous infusion of mesenchymal stem cells. The mesenchymal stem cells were obtained by bone marrow aspiration. The venous filling aspect of the distal end of the corpus cavernosum was evaluated and the specimens were submitted to histological analisis and to immunohistochemistry. Cavernosometry was done in one animal of each groupRESULTS:
Three animals on B and three animals on C presented full filling of distal end of the corpus cavernosum. No animals in A presented filling of the distal end of corpus cavernosum. At cavernosometry the animal on B attained 50 cmH2O, on C 110 cmH2O and on A 20 cmH2O. Trabeculae forming cavernous sinuses were found in groups B and C.CONCLUSION:
The reconstruction of corpus cavernosum using descellularized matrices and mesenchymal stem cells, either by intravenous injection or directly seeded is possible, with growth of corpus cavernosum-like tissue.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Penis
/
Plastic Surgery Procedures
/
Mesenchymal Stem Cell Transplantation
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2015
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de São Paulo/BR