Systemic lupus erythematosus and Raynaud's phenomenon
An. bras. dermatol
; 90(6): 837-840, Nov.-Dec. 2015. tab
Article
in English
| LILACS
| ID: lil-769525
Responsible library:
BR1.1
ABSTRACT
Abstract BACKGROUND:
Patients with systemic lupus erythematosus seem to belong to different serological and clinical subgroups of the disease. Genetic background can cause the appearance of these subgroups.OBJECTIVE:
To determine whether Brazilian patients who have systemic lupus erythematosus and Raynaud's phenomenon differ from those who do not.METHODS:
Retrospective analysis of 373 medical records of systemic lupus erythematosus patients studied for demographic, clinical and serological data. A comparative analysis was performed of individuals with and without RP.RESULTS:
There was a positive association between Raynaud's phenomenon and age at diagnosis (p=0.02), presence of anti-Sm (p=0.01) antibodies and anti-RNP (p<0.0001). Furthermore, a negative association was found between Raynaud's phenomenon and hemolysis (p=0.01), serositis (p=0.01), glomerulonephritis (p=0.0004) and IgM aCL (p=0.004) antibodies.CONCLUSION:
Raynaud's phenomenon patients appear to belong to a systemic lupus erythematosus subset with a spectrum of clinical manifestations located in a more benign pole of the disease.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Raynaud Disease
/
Lupus Erythematosus, Systemic
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2015
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade Evangélica do Paraná/BR