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Heterogenic colonization patterns by Leptospira interrogans in Rattus norvegicus from urban slums
Santos, Ana Amélia Nunes; Figueira, Cláudio Pereira; Reis, Mitermayer Galvão dos; Costa, Federico; Ristow, Paula.
Affiliation
  • Santos, Ana Amélia Nunes; Fundação Oswaldo Cruz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
  • Figueira, Cláudio Pereira; Fundação Oswaldo Cruz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
  • Reis, Mitermayer Galvão dos; Fundação Oswaldo Cruz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
  • Costa, Federico; Fundação Oswaldo Cruz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
  • Ristow, Paula; Fundação Oswaldo Cruz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
Braz. j. microbiol ; 46(4): 1161-1164, Oct.-Dec. 2015. tab, graf
Article in English | LILACS | ID: lil-769663
Responsible library: BR1.1
ABSTRACT
Abstract We evaluated the renal colonization by Leptospira interrogans in Rattus norvegicus (rats), as it is the major natural reservoir of urban leptospirosis. We caught 72 R. norvegicus, out of which 32 were found to be positive for L. interrogans by immunofluorescence assay. From these rats, we selected 17 and divided them into six groups based on the mass-age/sex. We performed the immunohistochemistry test against L. interrogans in the kidney sections of the rats and systematically counted the colonized tubules (CTs) in 20 fields. The proportion of positive fields varied from 5% to 95%. The number of CTs in 20 fields varied from 0.5 to 85.5. These differences were not related to age or sex of the animals. The characterization of leptospiral colonization patterns in the natural reservoirs is important to better understand the host-pathogen interactions in leptospirosis.
Subject(s)


Full text: Available Collection: International databases Database: LILACS Main subject: Rodent Diseases / Genetic Variation / Genotype / Leptospira interrogans / Leptospirosis Limits: Animals Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2015 Document type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz/BR

Full text: Available Collection: International databases Database: LILACS Main subject: Rodent Diseases / Genetic Variation / Genotype / Leptospira interrogans / Leptospirosis Limits: Animals Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2015 Document type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz/BR
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