Heterogenic colonization patterns by Leptospira interrogans in Rattus norvegicus from urban slums
Braz. j. microbiol
; 46(4): 1161-1164, Oct.-Dec. 2015. tab, graf
Article
in English
| LILACS
| ID: lil-769663
Responsible library:
BR1.1
ABSTRACT
Abstract We evaluated the renal colonization by Leptospira interrogans in Rattus norvegicus (rats), as it is the major natural reservoir of urban leptospirosis. We caught 72 R. norvegicus, out of which 32 were found to be positive for L. interrogans by immunofluorescence assay. From these rats, we selected 17 and divided them into six groups based on the mass-age/sex. We performed the immunohistochemistry test against L. interrogans in the kidney sections of the rats and systematically counted the colonized tubules (CTs) in 20 fields. The proportion of positive fields varied from 5% to 95%. The number of CTs in 20 fields varied from 0.5 to 85.5. These differences were not related to age or sex of the animals. The characterization of leptospiral colonization patterns in the natural reservoirs is important to better understand the host-pathogen interactions in leptospirosis.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Rodent Diseases
/
Genetic Variation
/
Genotype
/
Leptospira interrogans
/
Leptospirosis
Limits:
Animals
Language:
English
Journal:
Braz. j. microbiol
Journal subject:
Microbiology
Year:
2015
Document type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Oswaldo Cruz/BR