Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats
Rev. bras. farmacogn
; 26(1): 83-88, Jan.-Feb. 2016. tab, graf
Article
in English
| LILACS
| ID: lil-772645
Responsible library:
BR1.1
ABSTRACT
Abstract The aim of the present study was to assess the activity of the hazelnut oil in the treatment of polycystic ovary syndrome in rats. Serum follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, testosterone, serum lipid parameters, leptin and glucose levels were evaluated. Moreover, antioxidant activity was tested using superoxide dismutase, malondialdehyde, catalase, glutathione peroxidase levels. The phytosterol content of the oil was determined by HPLC. The plasma high density lipoprotein-cholesterol level was found to be significantly high and leptin and glucose concentrations were found to be significantly low in the treatment group. According to the phytochemical analysis, the main components of the oil were detected as α-tocopherol, γ-tocopherol, squalene, β-sitosterol, campesterol and stigmasterol. Corylus avellana oil was found to be effective in the treatment of polycystic ovary syndrome via regulating gonadotropins, steroids and serum lipid parameters and possesses antioxidant activity.
Full text:
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Collection:
International databases
Database:
LILACS
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2016
Document type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Gazi University/TR