Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner
Braz. j. med. biol. res
; 49(9): e5235, 2016. tab, graf
Article
in English
| LILACS
| ID: lil-788945
Responsible library:
BR1.1
ABSTRACT
Improving overall health and quality of life, preventing diseases and increasing life expectancy are key concerns in the field of public health. The search for antioxidants that can inhibit oxidative damage in cells has received a lot of attention. Rosmarinus officinalis L. represents an exceptionally rich source of bioactive compounds with pharmacological properties. In the present study, we explored the effects of the ethanolic extract of R. officinalis (eeRo) on stress resistance and longevity using the non-parasitic nematode Caenorhabditis elegans as a model. We report for the first time that eeRo increased resistance against oxidative and thermal stress and extended C. elegans longevity in an insulin/IGF signaling pathway-dependent manner. These data emphasize the eeRo beneficial effects on C. elegans under stress.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Stress, Physiological
/
Caenorhabditis elegans
/
Oxidative Stress
/
Rosmarinus
/
Longevity
Type of study:
Prognostic study
Aspects:
Patient-preference
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2016
Document type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Santa Maria/BR