Opioid peptides and gastrointestinal symptoms in autism spectrum disorders
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 38(3): 243-246, July-Sept. 2016.
Article
in English
| LILACS
| ID: lil-792749
Responsible library:
BR1.1
ABSTRACT
Autism spectrum disorders (ASDs) are characterized by deficits in the individual’s ability to socialize, communicate, and use the imagination, in addition to stereotyped behaviors. These disorders have a heterogenous phenotype, both in relation to symptoms and regarding severity. Organic problems related to the gastrointestinal tract are often associated with ASD, including dysbiosis, inflammatory bowel disease, exocrine pancreatic insufficiency, celiac disease, indigestion, malabsorption, food intolerance, and food allergies, leading to vitamin deficiencies and malnutrition. In an attempt to explain the pathophysiology involved in autism, a theory founded on opioid excess has been the focus of various investigations, since it partially explains the symptomatology of the disorder. Another hypothesis has been put forward whereby the probable triggers of ASDs would be related to the presence of bacteria in the bowel, oxidative stress, and intestinal permeability. The present update reviews these hypotheses.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
/
SDG3 -Target 3.5 Prevention and treatment of consumption of psychoactive substances
Health problem:
Target 3.5: Prevention and treatment of consumption of psychoactive substances
/
Diarrhea
/
Zoonoses
/
Opioid Abuse
Database:
LILACS
Main subject:
Opioid Peptides
/
Autism Spectrum Disorder
/
Gastrointestinal Diseases
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2016
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Escola Bahiana de Medicina e Saúde Pública (BAHIANA)/BR