Antimicrobial activity pf kaurenoic acid derivatives substituted on carbon-15

Davino, S. C; Giesbrecht, A. M; Roque, N. F

Davino, S. C; Giesbrecht, A. M; Roque, N. F.

Braz. j. med. biol. res ; 22(9): 1127-9, 1989. tab, ilus

Article in English | LILACS | ID: lil-83188

Responsible library: BR26.1

ABSTRACT

ABSTRACT

The antibacterial and antifungic activities of two kaurenic acids, ent kaurenoic acid and cinnamoylgrandifloric acid isolated from a hexane extract of aerial parts of Mikania laevigata, were investigated and compared with the activities of other kaurenic acid-derivatives substituted on carbon-15. Only acetylgrandifloric acid (en-kaur-16-en-15 alfa-acetyloxy-19-oic) and its epimer xylopic acid (ent-kaur-16-4n-15 beta-acetyloxy-19-oic) displayed significant antibacterial activity at concentrations >=250 microng/ml., the 15 alfa epimer being the most active

Subject(s)

Bacteria/drug effects; Diterpenes/pharmacology; Fungi/drug effects; Bacillus cereus/drug effects; Brazil; Chemistry; Plant Extracts/pharmacology; Plants, Medicinal; Staphylococcus aureus/drug effects; Staphylococcus epidermidis/drug effects

Search on Google

Add to My VHL

XML

Collection: International databases Database: LILACS Main subject: Bacteria / Diterpenes / Fungi Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1989 Document type: Article / Congress and conference / Project document

Search on Google

Add to My VHL

XML