Chronically inflamed tissue activates plasma mediators of vascular permeability
Braz. j. med. biol. res
; 23(2): 179-85, 1990. tab, ilus
Article
in English
| LILACS
| ID: lil-85155
Responsible library:
BR26.1
RESUMO
After inflammation was induced in the foot-pad of rats with nistatin or BCG, injection of "non-activated" homologous plasma at the inflamed site caused a significant increase in the vascular permeability of the lesions (Evans blue test), which was more intense in older lesions, increasing from 7.83 + or - 1.11 to 8.70 + or - 1.18 (nistatin, 4 and 21 days) and 7.30 + or - 0.66 to 7.54 + or - 0.80 (BCG, 4 and 21 days). Steroidal (acetyltriamcinolone, 25 mg/kg) and non-steroidal (indomethacin, 2 mg/kg) anti-inflammatory drugs markedly decreased this effect on 14-day old lesions induced by nistatin plus "non-activated" plasma (2.37 + or - 0.10 for acetyltriamcinolone treatment vs 8.15 + or - 1.22 for untreated animals; 3.34 + or - 0.41 for indomethacin treatment vs 8.15 + or - 1.22 for untreated animals) and BCG plus "non-activated" plasma (1.67 + or - 0.11 for acetyltriamcinolne treatment vs 10.27 + or - 0.52 for untreated animals; 5.87 + or - 0.35 for indomethacin treatment vs 9.14 + or - 0.23 for untreated animals). These data suggest that an increase in exudation in chronic lesions might result in "reactivation" of the process as observed clinically, for example, in rheumatoid arthritis in man
Search on Google
Collection:
International databases
Database:
LILACS
Main subject:
Plasma
/
Capillary Permeability
/
Inflammation
/
Anti-Inflammatory Agents
/
Mycobacterium bovis
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1990
Document type:
Article