Psychophysiological effects and dose equivalence of zopiclone and triazolam administered to healthy volunteers. Methodological considerations
Braz. j. med. biol. res
; 23(10): 941-51, 1990. ilus
Article
in English
| LILACS
| ID: lil-91630
Responsible library:
BR26.1
ABSTRACT
1. Dose-equivalence studies of zopiclone and triazolam were out. 2. Zopiclone (6.25, 8.75 and 11.25 mg), triazolam (0.1875, 0.275 and 0.5 mg) and placebo were given in the morining to 14 healty male volinteers aged 20-25 years under double-blind conditions according to an incomplete block design. Each patient received three of the seven possible treatment at intervals of at least 1 week. Subjects were evaluated using physiological measures, rating scales and memory taskes before and 1.5h after drug administration. 3. The sedative and amnestic effects of zopiclone were qualitatively similar to those of triazolam, with the highest dose of each havin the greatest effect. 4. On the basis of the digit symbol substitution test, 10 mg of zopiclone is equivalent to 0.5 mg of triazolam. Methodological problems of the experimetnal design of dose-equivalence studies are discussed
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Collection:
International databases
Database:
LILACS
Main subject:
Piperazines
/
Psychomotor Performance
/
Sleep
/
Triazolam
/
Hypnosis
/
Hypnotics and Sedatives
/
Memory
Type of study:
Controlled clinical trial
Limits:
Humans
/
Male
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1990
Document type:
Article