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Pentavalent antimonial nephrotoxicity in the rat
Veiga, J. P. R; Khanam, R; Rosa, T. T; Junqueira Junior, L. F; Brand, P. C; Raick, A. N; Friedman, H; Marsden, P. D.
Rev. Inst. Med. Trop. Säo Paulo ; 32(4): 304-9, jul.-ago. 1990. ilus
Article in English | LILACS | ID: lil-91913
Responsible library: BR66.1
RESUMO
Estudou-se a funcao renal de ratos tratados com Glucantime (Antimoniato de Meglumine, Rhodia) e Pentostam (estibogloconato de Sodio, Wellcome) na dose de 30 mg de "Sb POT v" por 100g de peso por dia, durante 30 dias. Observou-se um disturbio na concentracao urinaria, que foi reversivel 7 dias apos cessada a administracao das drogas. O estudo histopatologico do rim, por meio da microscopia optica, nao evidenciou alteracoes significativas. Por outro lado, ratos tratados com altas doses dos antimoniais (220mg de "Sb POT v" por 100g de peso por dia) mostraram alteracoes funcionais e histopatologicas renais compativeis com necrose tubular aguda
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Full text: Available Collection: International databases Database: LILACS Main subject: Organometallic Compounds / Kidney / Meglumine Limits: Animals Language: English Journal: Rev. Inst. Med. Trop. Säo Paulo Journal subject: Tropical Medicine Year: 1990 Document type: Article / Project document
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Full text: Available Collection: International databases Database: LILACS Main subject: Organometallic Compounds / Kidney / Meglumine Limits: Animals Language: English Journal: Rev. Inst. Med. Trop. Säo Paulo Journal subject: Tropical Medicine Year: 1990 Document type: Article / Project document