Exogenous ganglioside stimulation of axonal regeneration after new transection and entubulation repair
Braz. j. med. biol. res
; 23(9): 823-6, 1990. ilus
Article
in English
| LILACS
| ID: lil-92403
Responsible library:
BR26.1
ABSTRACT
Adult male mice received sciatic nerve transection at the midthigh level and both nerve stumps were sutured into a polythylene tube (PT) to bridge a nerve gap of 4 mm. The tubes were implanted either empty, or filled with collagen alone or in combination with gangliosides (GM1, GD1a, GD1b, anhd GT1b). Following a survival time of 6 weeks, the PT with the regenerating nerve cables were processed for plastic embedding, and morphometric measurements were made on myelinated and unmyelinated axons. The data suggest that local application of exogenous gangliosides causes a stimulation of axonal sprouting in vivo with no effefct on the rate of axonal maturation
Search on Google
Collection:
International databases
Database:
LILACS
Main subject:
Sciatic Nerve
/
Gangliosides
/
Nerve Regeneration
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1990
Document type:
Article
/
Congress and conference