The antiadrenergic effects of hypermagnesemia: an experimental study
Braz. j. med. biol. res
; 24(1): 29-33, jan.-mar. 1991. ilus
Article
in En
| LILACS
| ID: lil-99577
Responsible library:
BR26.1
ABSTRACT
The circulatory effects of norepinephrine (4 * g/kg) and phenylephrine (20 */kg) were determined in anesthetized dogs withnormal plasma magnesium and with induced hypermagnesemia. Norepinephrine caused a 24% increased in heart rate by 103% increase in the systemic vascular, resistance index in normomagnesemic dogs, while with hypermagnesemia the variations were of 13% and 1%, respectively. Isoproterenol increased heart rate by 485 and 185 in dogs with normo- and hypermagnesemia, respectively.Phenylephrine increased the systemic vascular resistance index (74%) only in the normomagnesemic state.The effects of all the drugs were significantly defferent (P<0.01), without and with the simultaneous administration of magnesium sulfate (plasma magnesium, 1.3ñ0.2mEq/l and 6.8ñ1.1 mEq/l, respectively).We conclude that acute induced hypermagnesemia antagonizes the circulatory effects of adrenergic stimulation, a fact that may explain its antiarrhythmic and hemodynamic effects during acute myocardial ischemia
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Collection:
01-internacional
Database:
LILACS
Main subject:
Phenylephrine
/
Norepinephrine
/
Hemodynamics
/
Isoproterenol
/
Magnesium
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1991
Document type:
Article
Country of publication:
Brazil