Your browser doesn't support javascript.
loading
Resolution of an infection with Leishmania braziliensis confers complete protection to a subsequent challenge with Leishmania major in BALB/c mice.
Lima, H C; DeKrey, G K; Titus, R G.
Affiliation
  • Lima HC; Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523-1671, USA.
Mem Inst Oswaldo Cruz ; 94(1): 71-6, 1999.
Article in En | MEDLINE | ID: mdl-10029914
Both Leishmania major and L. braziliensis induce cutaneous leishmaniasis in BALB/c mice. Whereas BALB/c mice die of infection with L. major, they cure an infection with L. braziliensis. We report here that after curing an infection with L. braziliensis, BALB/c mice are resistant to challenge with L. major. When challenged with L. major, L. braziliensis pre-treated BALB/c mice mounted a delayed-type hypersensitivity response to L. major and produced high amounts of interferon-gamma (IFN-gamma) but low amounts of interleukin-4. The IFN-gamma produced by the L. braziliensis pre-infected mice was involved in the protection seen against L. major challenge since treating the mice with a neutralizing anti-IFN-gamma abrogated the protection. This suggests that cross-reactive antigen epitopes exist between L. braziliensis and L. major and that pre-infection with L. braziliensis primes BALB/c mice to epitopes on L. major that can elicit a protective Th1 response to the parasite.
Subject(s)
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Leishmania braziliensis / Leishmaniasis, Cutaneous / Leishmania major Limits: Animals Country/Region as subject: America do sul / Brasil Language: En Journal: Mem Inst Oswaldo Cruz Year: 1999 Document type: Article Affiliation country: United States Country of publication: Brazil
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Leishmania braziliensis / Leishmaniasis, Cutaneous / Leishmania major Limits: Animals Country/Region as subject: America do sul / Brasil Language: En Journal: Mem Inst Oswaldo Cruz Year: 1999 Document type: Article Affiliation country: United States Country of publication: Brazil