alpha-Interferon therapy for HBV-related glomerulonephritis.
Sao Paulo Med J
; 116(5): 1823-5, 1998.
Article
in En
| MEDLINE
| ID: mdl-10030109
We report a case of a patient with hepatitis B virus (HBV)-related membranous glomerulonephritis (MGN) who showed improvement after interferon-alpha (IFN-alpha) therapy. A 35-year-old man with nephrotic syndrome and HBV antigens received a 24-week course of IFN-alpha. At the end of therapy there was an elevation in the level of plasma aminotransferase and an increase in proteinuria, which were followed by antigen/antibody seroconversion. This "flare-up" before seroconversion suggests an increase in disease activity in the liver and kidney, demonstrating in vivo HBV involvement in MGN.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Glomerulonephritis, Membranous
/
Interferon-alpha
/
Hepatitis B
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Sao Paulo Med J
Journal subject:
MEDICINA
Year:
1998
Document type:
Article
Country of publication:
Brazil