Nitric oxide synthase inhibitor decreases NMDA-induced elevations of extracellular glutamate and intracellular Ca2+ levels via a cGMP-independent mechanism in cerebellar granule neurons.

Oh, S; Yun, B S; Ryoo, I J; McCaslin, P P; Yoo, I D

Oh, S; Yun, B S; Ryoo, I J; McCaslin, P P; Yoo, I D.

Affiliation

Oh S; Korea Research Institute of Bioscience and Biotechnology, Cell Function Regulator, Yusong, Taejon.

Arch Pharm Res ; 22(1): 48-54, 1999 Feb.

Article in En | MEDLINE | ID: mdl-10071959

Subject(s)

Calcium/metabolism; Cerebellum/metabolism; Cyclic GMP/physiology; Excitatory Amino Acid Agonists/pharmacology; Glutamic Acid/metabolism; N-Methylaspartate/pharmacology; Neurons/metabolism; Nitric Oxide Synthase/antagonists & inhibitors; omega-N-Methylarginine/pharmacology; Animals; Cells, Cultured; Cerebellum/cytology; Cerebellum/drug effects; Dibutyryl Cyclic GMP/pharmacology; Extracellular Space/metabolism; Neurons/drug effects; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Cerebellum / Calcium / N-Methylaspartate / Cyclic GMP / Glutamic Acid / Excitatory Amino Acid Agonists / Nitric Oxide Synthase / Omega-N-Methylarginine / Neurons Limits: Animals Language: En Journal: Arch Pharm Res Year: 1999 Document type: Article Country of publication:

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