CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes.

Boonen, G J; van Dijk, A M; Verdonck, L F; van Lier, R A; Rijksen, G; Medema, R H

Boonen, G J; van Dijk, A M; Verdonck, L F; van Lier, R A; Rijksen, G; Medema, R H.

Affiliation

Boonen GJ; Department of Haematology, University Hospital Utrecht, The Netherlands.

Eur J Immunol ; 29(3): 789-98, 1999 03.

Article in En | MEDLINE | ID: mdl-10092081

Subject(s)

CD28 Antigens/biosynthesis; CDC2-CDC28 Kinases; Cell Cycle Proteins; Down-Regulation; Interleukin-2/physiology; Microtubule-Associated Proteins/biosynthesis; T-Lymphocytes/metabolism; Tumor Suppressor Proteins; Cell Cycle; Cell Line; Cyclin D3; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases/metabolism; Cyclins/biosynthesis; Humans; Immunosuppressive Agents/pharmacology; Interleukin-2/pharmacology; Phosphorylation; Protein Serine-Threonine Kinases/metabolism; Retinoblastoma Protein/metabolism; T-Lymphocytes/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Down-Regulation / Interleukin-2 / CD28 Antigens / Cell Cycle Proteins / Tumor Suppressor Proteins / CDC2-CDC28 Kinases / Microtubule-Associated Proteins Limits: Humans Language: En Journal: Eur J Immunol Year: 1999 Document type: Article Affiliation country: Netherlands Country of publication: Germany

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