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Studies on IgA class circulatory red cell antibodies--II. Properties of IgA class anti-A,anti-B.
Booth, J R; Sokol, R J.
Affiliation
  • Booth JR; Trent Blood Transfusion Centre, Sheffield, U.K.
Transfus Sci ; 16(2): 161-6, 1995 Jun.
Article in En | MEDLINE | ID: mdl-10155733
The properties of IgA class red cell alloantibodies were determined using an anti-A,anti-B preparation confirmed to be free from IgG and IgM. The following characteristics were found: a thermal optimum of 37 degrees C; saline agglutination enhanced by anti-human IgA; activity substantially unchanged after 1 year's storage at 4 degrees C, but reduced by papain and destroyed by pepsin and by reduction and alkylation; neutralization by AB blood group substance; an inability to activate complement; and a distinctive pattern of apparent molecular sizes (reflecting dimeric and monomeric forms and complexes with serum proteins) which was significantly altered by the action of enzymes and by reduction and alkylation.
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Collection: 01-internacional Database: MEDLINE Main subject: ABO Blood-Group System / Immunoglobulin A / Erythrocytes / Isoantibodies Limits: Humans Language: En Journal: Transfus Sci Year: 1995 Document type: Article Country of publication: United kingdom
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Collection: 01-internacional Database: MEDLINE Main subject: ABO Blood-Group System / Immunoglobulin A / Erythrocytes / Isoantibodies Limits: Humans Language: En Journal: Transfus Sci Year: 1995 Document type: Article Country of publication: United kingdom