Stability and DNA alkylation rates of the simplest functional analogues of CC-1065, para-hydroxy and para-amino phenethyl bromides.

Shalders, R L; Blanch, G; Brown, C L; Young, D J; Prakash, A S

Shalders, R L; Blanch, G; Brown, C L; Young, D J; Prakash, A S.

Affiliation

Shalders RL; National Research Centre for Environmental Toxicology, Coopers Plains, QLD, Australia.

Chem Biol Interact ; 117(1): 83-94, 1999 Jan 01.

Article in En | MEDLINE | ID: mdl-10190546

Subject(s)

Antibiotics, Antineoplastic/metabolism; DNA/metabolism; Hydrocarbons, Brominated/metabolism; Hydroxybenzoates/metabolism; Indoles; Leucomycins/metabolism; Adenine/metabolism; Alkylation; Antibiotics, Antineoplastic/chemistry; Antibiotics, Antineoplastic/toxicity; Base Sequence; Computer Simulation; Duocarmycins; HeLa Cells/drug effects; Humans; Leucomycins/chemistry; Leucomycins/toxicity; Models, Chemical; Molecular Sequence Data; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: DNA / Leucomycins / Hydrocarbons, Brominated / Hydroxybenzoates / Indoles / Antibiotics, Antineoplastic Type of study: Prognostic_studies Limits: Humans Language: En Journal: Chem Biol Interact Year: 1999 Document type: Article Affiliation country: Australia Country of publication: Ireland

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