Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis.

Rittner, H L; Hafner, V; Klimiuk, P A; Szweda, L I; Goronzy, J J; Weyand, C M

Rittner, H L; Hafner, V; Klimiuk, P A; Szweda, L I; Goronzy, J J; Weyand, C M.

Affiliation

Rittner HL; Department of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota 55905, USA.

J Clin Invest ; 103(7): 1007-13, 1999 Apr.

Article in En | MEDLINE | ID: mdl-10194473

Subject(s)

Aldehyde Reductase/physiology; Giant Cell Arteritis/enzymology; Imidazolidines; Lipid Peroxidation; Vasculitis/enzymology; Aldehyde Reductase/antagonists & inhibitors; Aldehyde Reductase/genetics; Aldehydes/metabolism; Aldehydes/toxicity; Animals; Apoptosis/drug effects; Apoptosis/genetics; Benzothiazoles; Chimera/genetics; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/therapeutic use; Free Radical Scavengers/metabolism; Giant Cell Arteritis/genetics; Humans; Imidazoles/pharmacology; Imidazoles/therapeutic use; Mice; Mice, SCID; Phthalazines/pharmacology; Phthalazines/therapeutic use; RNA, Messenger/metabolism; Temporal Arteries/enzymology; Temporal Arteries/pathology; Thiazoles/pharmacology; Thiazoles/therapeutic use; Up-Regulation/genetics; Vasculitis/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Giant Cell Arteritis / Vasculitis / Lipid Peroxidation / Aldehyde Reductase / Imidazolidines Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 1999 Document type: Article Affiliation country: United States Country of publication: United States

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