Heterocyclic aromatic amines induce DNA strand breaks and cell transformation.

Pfau, W; Martin, F L; Cole, K J; Venitt, S; Phillips, D H; Grover, P L; Marquardt, H

Pfau, W; Martin, F L; Cole, K J; Venitt, S; Phillips, D H; Grover, P L; Marquardt, H.

Affiliation

Pfau W; Fraunhofer Society, Department of Toxicology and Environmental Medicine, Hamburg University Medical School, Germany. pfau@uke.uni-hamburg.de

Carcinogenesis ; 20(4): 545-51, 1999 Apr.

Article in En | MEDLINE | ID: mdl-10223180

Subject(s)

Carcinogens, Environmental/toxicity; Cell Transformation, Neoplastic/chemically induced; DNA Damage; Imidazoles/toxicity; Quinoxalines/toxicity; Animals; Biotransformation; Carbolines/toxicity; Cytochrome P-450 Enzyme System/metabolism; Dose-Response Relationship, Drug; Fibroblasts/drug effects; Food; Hot Temperature; Humans; Lymphocytes/drug effects; Male; Mice; Mice, Inbred C3H; Micronucleus Tests; Microsomes, Liver/metabolism; Mutagenicity Tests; Mutagens/toxicity; Quinolines/toxicity; Rats; Salmonella typhimurium/drug effects; Salmonella typhimurium/genetics; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Quinoxalines / DNA Damage / Carcinogens, Environmental / Cell Transformation, Neoplastic / Imidazoles Limits: Animals / Humans / Male Language: En Journal: Carcinogenesis Year: 1999 Document type: Article Affiliation country: Germany

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