Properties and pharmacokinetics of two humanized antibodies specific for L-selectin.

Co, M S; Landolfi, N F; Nagy, J O; Tan, J H; Vexler, V; Vasquez, M; Roark, L; Yuan, S; Hinton, P R; Melrose, J; Klingbeil, C; Queen, C; Berg, E L

Co, M S; Landolfi, N F; Nagy, J O; Tan, J H; Vexler, V; Vasquez, M; Roark, L; Yuan, S; Hinton, P R; Melrose, J; Klingbeil, C; Queen, C; Berg, E L.

Affiliation

Co MS; Protein Design Labs, Inc., Fremont, CA 94555, USA.

Immunotechnology ; 4(3-4): 253-66, 1999 Mar.

Article in En | MEDLINE | ID: mdl-10231094

Subject(s)

Antibodies, Monoclonal/immunology; Antibodies, Monoclonal/pharmacokinetics; Antibody Affinity; L-Selectin/immunology; Amino Acid Sequence; Animals; Antibodies, Monoclonal/genetics; Antibody Specificity; Cell Adhesion; Cloning, Molecular; Cross Reactions; Endothelium, Lymphatic/metabolism; Humans; Immunoglobulin Heavy Chains/genetics; Immunoglobulin Heavy Chains/immunology; Immunoglobulin Heavy Chains/metabolism; Immunoglobulin Light Chains/genetics; Immunoglobulin Light Chains/immunology; Immunoglobulin Light Chains/metabolism; Immunoglobulin Variable Region/genetics; Immunoglobulin Variable Region/immunology; Immunoglobulin Variable Region/metabolism; Leukocytes/cytology; Leukocytes/metabolism; Liposomes/metabolism; Macaca mulatta; Mice; Molecular Sequence Data; Protein Engineering; Recombinant Proteins/chemistry; Recombinant Proteins/immunology; Species Specificity; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: L-Selectin / Antibodies, Monoclonal / Antibody Affinity Limits: Animals / Humans Language: En Journal: Immunotechnology Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 1999 Document type: Article Affiliation country: United States Country of publication: Netherlands

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