Complement-mediated injury reversibly disrupts glomerular epithelial cell actin microfilaments and focal adhesions.

Topham, P S; Haydar, S A; Kuphal, R; Lightfoot, J D; Salant, D J

Topham, P S; Haydar, S A; Kuphal, R; Lightfoot, J D; Salant, D J.

Affiliation

Topham PS; Evans Department of Medicine and Clinical Research, Boston University Medical Center, Massachusetts, USA.

Kidney Int ; 55(5): 1763-75, 1999 May.

Article in En | MEDLINE | ID: mdl-10231439

Subject(s)

Actins/metabolism; Complement System Proteins/immunology; Glomerulonephritis/immunology; Kidney Glomerulus/cytology; Kidney Glomerulus/immunology; Actin Cytoskeleton/chemistry; Actin Cytoskeleton/drug effects; Actin Cytoskeleton/metabolism; Animals; Blotting, Western; Cell Adhesion/immunology; Cell Adhesion Molecules/analysis; Cell Line; Complement Membrane Attack Complex/chemistry; Complement Membrane Attack Complex/immunology; Cycloheximide/pharmacology; Cytoskeletal Proteins/analysis; Epithelial Cells/chemistry; Epithelial Cells/cytology; Epithelial Cells/enzymology; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glomerulonephritis/metabolism; Immunoglobulin G/pharmacology; Integrin alpha3beta1; Integrins/analysis; Paxillin; Phosphoproteins/analysis; Phosphotyrosine/analysis; Phosphotyrosine/immunology; Protein Synthesis Inhibitors/pharmacology; Protein-Tyrosine Kinases/analysis; Rats; Receptors, Laminin/analysis; Talin/analysis; Vanadates/pharmacology; Vinculin/analysis

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Collection: 01-internacional Database: MEDLINE Main subject: Complement System Proteins / Actins / Glomerulonephritis / Kidney Glomerulus Language: En Journal: Kidney Int Year: 1999 Document type: Article Affiliation country: United States

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