A pharmacokinetic/pharmacodynamic model for recombinant human growth hormone effects on induction of insulin-like growth factor I in monkeys.

Sun, Y N; Lee, H J; Almon, R R; Jusko, W J

Sun, Y N; Lee, H J; Almon, R R; Jusko, W J.

Affiliation

Sun YN; Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York, USA.

J Pharmacol Exp Ther ; 289(3): 1523-32, 1999 Jun.

Article in En | MEDLINE | ID: mdl-10336548

Subject(s)

Human Growth Hormone/pharmacology; Human Growth Hormone/pharmacokinetics; Insulin-Like Growth Factor I/biosynthesis; Animals; Delayed-Action Preparations; Drug Administration Schedule; Growth Hormone/administration & dosage; Growth Hormone/pharmacokinetics; Growth Hormone/pharmacology; Human Growth Hormone/administration & dosage; Humans; Infusions, Intravenous; Injections, Subcutaneous; Kinetics; Macaca mulatta; Metabolic Clearance Rate; Microspheres; Models, Biological; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Insulin-Like Growth Factor I / Human Growth Hormone Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Pharmacol Exp Ther Year: 1999 Document type: Article Affiliation country: United States

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