Early arrest in B cell development in transgenic mice that express the E41K Bruton's tyrosine kinase mutant under the control of the CD19 promoter region.

Maas, A; Dingjan, G M; Grosveld, F; Hendriks, R W

Maas, A; Dingjan, G M; Grosveld, F; Hendriks, R W.

Affiliation

Maas A; Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands.

J Immunol ; 162(11): 6526-33, 1999 Jun 01.

Article in En | MEDLINE | ID: mdl-10352268

Subject(s)

Antigens, CD19/genetics; B-Lymphocyte Subsets/enzymology; Glutamic Acid/genetics; Lysine/genetics; Point Mutation/immunology; Promoter Regions, Genetic/immunology; Protein-Tyrosine Kinases/genetics; Agammaglobulinaemia Tyrosine Kinase; Agammaglobulinemia/blood; Agammaglobulinemia/genetics; Animals; B-Lymphocyte Subsets/cytology; B-Lymphocyte Subsets/pathology; Cell Differentiation/genetics; Cell Differentiation/immunology; Gene Expression Regulation/immunology; Humans; Immunoglobulin G/biosynthesis; Immunoglobulin G/blood; Immunoglobulin M/biosynthesis; Immunoglobulin M/blood; Immunophenotyping; Lymphopenia/genetics; Lymphopenia/immunology; Lymphopenia/pathology; Mice; Mice, Transgenic; Plasma Cells/pathology; Protein-Tyrosine Kinases/biosynthesis; Spleen/cytology; Spleen/immunology; Spleen/pathology; Transgenes/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / B-Lymphocyte Subsets / Promoter Regions, Genetic / Point Mutation / Glutamic Acid / Antigens, CD19 / Lysine Limits: Animals / Humans Language: En Journal: J Immunol Year: 1999 Document type: Article Affiliation country: Netherlands Country of publication: United States

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