Influence of brain and azadirachtin on Trypanosoma cruzi development in the vector, Rhodnius prolixus.
Exp Parasitol
; 92(2): 100-8, 1999 Jun.
Article
in En
| MEDLINE
| ID: mdl-10366535
Studies on the effects of decapitation, head transplantation, azadirachtin, and ecdysone therapy on the ultrastructural organization of the midgut of Rhodnius prolixus, a vector of the protozoan Trypanosoma cruzi, show a distinct effect on the organization of the epithelial cells. When insects are decapitated or treated with azadirachtin, the ultrastructural organiza tion of these compartments changed significantly and drastically blocked the development of T. cruzi infection. In converse experiments, head transplantation or oral therapy with ecdysone significantly re versed the T. cruzi infectivity and reestablished the organization of the stomach and intestine in decapitated or azadirachtin-treated insects. These results indicat that a brain factor, possibly the prothoracicotropic hormone which stimulates ecdysteroid production on the prothoracic glands, may act directly or indirectly on both the midgut cell organiza tion and the intestinal microenvironment, interfering in the trypanosome survival and infection of the vector R. prolixus.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rhodnius
/
Triterpenes
/
Trypanosoma cruzi
/
Limonins
/
Insect Vectors
/
Insecticides
Limits:
Animals
Language:
En
Journal:
Exp Parasitol
Year:
1999
Document type:
Article
Affiliation country:
Brazil
Country of publication:
United States