Manipulation of the tetrahydrocannabinol side chain delineates agonists, partial agonists, and antagonists.

Martin, B R; Jefferson, R; Winckler, R; Wiley, J L; Huffman, J W; Crocker, P J; Saha, B; Razdan, R K

Martin, B R; Jefferson, R; Winckler, R; Wiley, J L; Huffman, J W; Crocker, P J; Saha, B; Razdan, R K.

Affiliation

Martin BR; Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA. Martinb@hsc.vcu.edu

J Pharmacol Exp Ther ; 290(3): 1065-79, 1999 Sep.

Article in En | MEDLINE | ID: mdl-10454479

Subject(s)

Dronabinol/chemical synthesis; Dronabinol/pharmacology; Psychotropic Drugs/chemical synthesis; Psychotropic Drugs/pharmacology; Receptors, Drug/agonists; Receptors, Drug/antagonists & inhibitors; Animals; Dronabinol/analogs & derivatives; Dronabinol/metabolism; Kinetics; Male; Mice; Mice, Inbred ICR; Molecular Conformation; Psychotropic Drugs/metabolism; Receptors, Cannabinoid; Receptors, Drug/metabolism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Psychotropic Drugs / Receptors, Drug / Dronabinol Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 1999 Document type: Article Affiliation country: United States

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