Inhalation of tobramycin in cystic fibrosis. Part 2: optimization of the tobramycin solution for a jet and an ultrasonic nebulizer.

Le Brun, P P; de Boer, A H; Gjaltema, D; Hagedoorn, P; Heijerman, H G; Frijlink, H W

Le Brun, P P; de Boer, A H; Gjaltema, D; Hagedoorn, P; Heijerman, H G; Frijlink, H W.

Affiliation

Le Brun PP; Central Hospital Pharmacy The Hague, P.O. Box 43100, 2504 AC, The Hague, The Netherlands.

Int J Pharm ; 189(2): 215-25, 1999 Nov 05.

Article in En | MEDLINE | ID: mdl-10536250

Subject(s)

Anti-Bacterial Agents/administration & dosage; Cystic Fibrosis/drug therapy; Tobramycin/administration & dosage; Administration, Inhalation; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/therapeutic use; Chemistry, Pharmaceutical/instrumentation; Dose-Response Relationship, Drug; Fluorescence Polarization Immunoassay; Humans; Kinetics; Nebulizers and Vaporizers; Particle Size; Pressure; Solutions; Tobramycin/chemistry; Tobramycin/therapeutic use; Ultrasonics

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Collection: 01-internacional Database: MEDLINE Main subject: Tobramycin / Cystic Fibrosis / Anti-Bacterial Agents Limits: Humans Language: En Journal: Int J Pharm Year: 1999 Document type: Article Affiliation country: Netherlands

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