Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand.

Alfaro-Lopez, J; Okayama, T; Hosohata, K; Davis, P; Porreca, F; Yamamura, H I; Hruby, V J

Alfaro-Lopez, J; Okayama, T; Hosohata, K; Davis, P; Porreca, F; Yamamura, H I; Hruby, V J.

Affiliation

Alfaro-Lopez J; Department of Chemistry, The University of Arizona, Tucson, Arizona 85721, USA.

J Med Chem ; 42(26): 5359-68, 1999 Dec 30.

Article in En | MEDLINE | ID: mdl-10639279

Subject(s)

Benzhydryl Compounds/chemistry; Benzhydryl Compounds/pharmacology; Piperazines/chemistry; Piperazines/pharmacology; Receptors, Opioid, delta/agonists; Animals; Benzhydryl Compounds/metabolism; Brain/drug effects; Guinea Pigs; In Vitro Techniques; Ligands; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Models, Molecular; Muscle, Smooth/drug effects; Piperazines/metabolism; Radioligand Assay; Rats; Receptors, Opioid, delta/metabolism; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Benzhydryl Compounds / Receptors, Opioid, delta Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1999 Document type: Article Affiliation country: United States

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