Metabolite-intermediate complexation and inhibition of microsomal CYP3A in rat liver by diltiazem.

Trieu, L; Murray, M

Trieu, L; Murray, M.

Affiliation

Trieu L; Storr Liver Unit, University of Sydney, Westmead Hospital, NSW, Australia.

Xenobiotica ; 30(2): 131-40, 2000 Feb.

Article in En | MEDLINE | ID: mdl-10718121

Subject(s)

Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme Inhibitors; Diltiazem/metabolism; Microsomes, Liver/enzymology; Oxidoreductases, N-Demethylating/antagonists & inhibitors; Steroid 16-alpha-Hydroxylase; Animals; Cytochrome P-450 CYP3A; Desipramine/metabolism; Desipramine/pharmacology; Dexamethasone/pharmacology; Diltiazem/pharmacology; Enzyme Inhibitors/pharmacology; Immunoblotting; Male; Microsomes, Liver/metabolism; NADP/metabolism; Phenobarbital/pharmacology; Rats; Rats, Wistar; Spectrophotometry; Steroid Hydroxylases/antagonists & inhibitors; Testosterone/metabolism; beta-Naphthoflavone/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases, N-Demethylating / Microsomes, Liver / Aryl Hydrocarbon Hydroxylases / Diltiazem / Steroid 16-alpha-Hydroxylase / Cytochrome P-450 Enzyme Inhibitors Limits: Animals Language: En Journal: Xenobiotica Year: 2000 Document type: Article Affiliation country: Australia

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